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NIK-IN-3

CAT: 0013-GTR19274250-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274250-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NIK-IN-3 is a potent, orally active inhibitor of NF-κB-inducing kinase (NIK) with an IC50 value of 5.2 nM. It effectively suppresses activation of the non-canonical NF-κB pathway and inhibits the secretion of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and the chemokine CXCL12. NIK-IN-3 demonstrates significant anti-inflammatory effects in LPS-induced sepsis and DSS-induced colitis mouse models. This compound is applicable in inflammation-related research, such as studies on colitis.
Storage Conditions
-20°C
Notes
For research use only.

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