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CIAC101

CAT: 0804-HY-179646Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179646Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC50 of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides (HY-D1056) (LPS) -induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6) . CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease[1].
UNSPSC
12352005
Target
Interleukin Related; NF-κB; NO Synthase; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C1[C@](OC2=C(OCC(C)C)C=CC3=C24)([H])[C@]54CCN(CC6CC6)[C@](C3)([H])[C@@]5(O)C=C1
Molecular Formula
C24H29NO4
Molecular Weight
395.49
References & Citations
[1]Gao J, et al. Nanomolar TLR4 Antagonist CIAC101 Derived from (+) -Naltrexone Blocks Microglial Activation and Methamphetamine Addiction. J Med Chem. 2025;68 (23) :25469-25484.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; iNOS; NF-κB; TLR4; TNFRSF5/CD40

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