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CIAC001

CAT: 0804-HY-155850-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155850-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC50=2.5 μM) . CIAC001 also has anti-neuroinflammation in mouse models and inhibits chronic morphine-induced addiction[1].
CAS Number
2649154-82-3
UNSPSC
12352005
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ciac001.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1N=CC=N1)C2=CC(O)=C(C(O)=C2)[C@@H]3C=C(CC[C@H]3C(C)=C)C
Molecular Formula
C20H25N3O2
Molecular Weight
339.43
References & Citations
[1]Jin S, et al. Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2. J Med Chem. 2023 Aug 24;66 (16) :11498-11516.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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