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MS102

CAT: 0804-HY-179630Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179630Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS102 is an orally active ubiquitin specific peptidase 2 (USP2) inhibitor with an IC50 of 5.46 μM. MS102 has viable antiviral activity against ACE2-dependent coronaviruses. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in vitro and in vivo. MS102 can be used for the study of SARS-CoV-2. MS102 can be used in combination with anti-PD-1 immunotherapy to enhance the anti-tumor immune response[1][2].
CAS Number
3058587-77-9
UNSPSC
12352005
Target
Deubiquitinase; SARS-CoV; VISTA
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C(NC1=NC(C2=CC=C(Br)C=C2)=CS1)C3=CC(C(F)(F)F)=CC=C3NS(=O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C24H17BrF3N3O3S2
Molecular Weight
596.44
References & Citations
[1]Dang F, et al. USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Sci Transl Med. 2023;15 (725) :eadh7668.|[2]Li Chen, et al. Targeted destruction of VISTA boosts anti-tumor immunotherapy. Cell Res. 2025 Dec;35 (12) :987-1002. 
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP2

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