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HTS10307

CAT: 0804-HY-179594Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179594Size:1 Each
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Description
HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease[1].
CAS Number
81682-91-9
UNSPSC
12352005
Target
AP-1
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Smiles
O=C(N1)C(C#N)=C(C2=CC=CO2)C=C1C3=CC=CS3
Molecular Formula
C14H8N2O2S
Molecular Weight
268.29
References & Citations
[1]Sean McNeme, et al. Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB. bioRxiv. October 23, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FosB

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