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SLC6A19-IN-4

CAT: 0804-HY-179581Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179581Size:1 Each
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Description
SLC6A19-IN-4 is an allosteric-competitive and orally active B⁰AT1 inhibitor. SLC6A19-IN-4 inhibits both human and mouse B⁰AT1b> with IC50 values of 513 nM and 295 nM, respectively. SLC6A19-IN-4 exhibits excellent metabolic stability. SLC6A19-IN-4 significantly increases urinary phenylalanine (Phe) excretion and reduces plasma Phe levels through dual inhibition of B⁰AT1 in both the intestine (reducing absorption) and kidney (promoting excretion) in vivo. SLC6A19-IN-4 can be used for phenylketonuria (PKU) and other disorders involving SLC6-family transporters research[1].
CAS Number
2962069-39-0
UNSPSC
12352005
Target
Amino acid Transporter
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease
Smiles
O=C(NCC(N1CC(NCC1)=O)=O)/C=C/C2=CC=C(C=C2)C(F)(F)F
Molecular Formula
C16H16F3N3O3
Molecular Weight
355.31
References & Citations
[1]Takuya Imazu, et al., Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria. bioRxiv. 2025.10.27.684712
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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