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IMQT_020

CAT: 0804-HY-179557Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179557Size:1 Each
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Description
IMQT_020 is a selective allosteric SLC1A5_var inhibitor. iMQT_020 disrupts the trimeric assembly of SLC1A5_var, causing metabolic crisis in cancer cells and selectively suppressing their growth. iMQT_020 reduces glutamine anaplerosis and oxidative phosphorylation, resulting in a broad disruption of cancer metabolism. iMQT_020 reduces GSH levels and increases cellular ROS and mitochondrial ROS. iMQT_020 induces apoptosis and ferroptosis. iMQT_020 can epigenetically upregulate PD-L1 expression. iMQT_020 can be used for the study of pancreatic cancer, lung cancer, and colon cancer[1].
CAS Number
2463893-46-9
UNSPSC
12352005
Target
Apoptosis; Ferroptosis; Glutathione Peroxidase; PD-1/PD-L1; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
ClC1=C(O)C=C(F)C(C2=CC=C(NC(NC3=O)=O)C3=C2)=C1
Molecular Formula
C14H8ClFN2O3
Molecular Weight
306.68
References & Citations
[1]Sung Y, et al. Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var. Nat Commun. 2025 Nov 3;16 (1) :9690.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19274116-01IMQT_020

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