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XSJ151

CAT: 0804-HY-179520Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179520Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XSJ151 is a topoisomerase I inhibitor, stabilizing the DNA-Topo I covalent complex and inducing DNA double-strand breaks. XSJ151-induced DNA damage activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, leading to G2/M phase cell cycle arrest and disrupting the dynamic homeostasis of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 can be used for the study of gastric cancer[1].
CAS Number
1685279-23-5
UNSPSC
12352005
Target
Bcl-2 Family; DNA/RNA Synthesis; MDM-2/p53; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
COC(C=C1)=CC=C1CC(NCC(O[C@]2(CC)C(OCC3=C2C=C4N(CC5=CC6=CC=CC=C6N=C54)C3=O)=O)=O)=NS(C7=CC=C([N+]([O-])=O)C=C7)(=O)=O
Molecular Formula
C37H31N5O10S
Molecular Weight
737.73
References & Citations
[1]Si Z, et al. Camptothecin 20 (S) -sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade. Bioorg Chem. 2025 Nov;166:109171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Topo I

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