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XSJ81

CAT: 0804-HY-175589Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175589Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XSJ81 is an orally active anti-cancer agent. XSJ81 significantly inhibits the proliferation of ampullary carcinoma (AC) DPC-X3 cells with an IC50 of 0.655 μM. XSJ81 inhibits the colony formation, arrests cell cycle at the G2/M phase and inhibits the migration in DPC-X3 cells. XSJ81 induces DNA damage and apoptosis in DPC-X3 cells. XSJ81 demonstrates significant anti-tumor efficacy in mice bearing DPC-X3 xenografts. XSJ81 can be used for the study of ampullary carcinoma[1].
UNSPSC
12352100
Target
Apoptosis; Bcl-2 Family; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC[C@]1(C(OC=C2C(N3CC4=CC5=CC=CC=C5N=C4C3CC21)=O)=O)OC(CNC(NS(=O)(C6=CC=C(C=C6)C)=O)=O)=O
Molecular Formula
C30H28N4O8S
Molecular Weight
604.63
References & Citations
[1]Du L, et al. Antitumor activity of XSJ81, a 20-sulfonated camptothecin derivative, targeting topoisomerase I against ampullary carcinoma. Bioorg Chem. 2025 Aug;163:108780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I

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