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Umbelopsisin A

CAT: 0804-HY-179519Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179519Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Umbelopsisin A is a GABAA and GABAB non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications[1].
UNSPSC
12352005
Target
GABA Receptor; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC1=C(O)C(C)=C(C)C([C@@]2(C3=CNC4=CC=CC=C43)C(OC)=O)=C1OC2=O
Molecular Formula
C21H19NO5
Molecular Weight
365.38
References & Citations
[1]Mo J, et al. A novel fungal alkaloid protects retinal ganglion cells against glutamate-induced excitotoxicity in vitro and in vivo via activation of GABA pathway. Bioorg Chem. 2025;166:109170.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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