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AKT1-IN-11

CAT: 0804-HY-179516Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179516Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKT1-IN-11, a Podophyllotoxin derivative, is a AKT1/tubulin dual inhibitor. AKT1-IN-11 down-regulates the phosphorylation level of AKT kinase in tumor cells, disrupting cell proliferation, causeing G2/M phase arrest and inducing apoptosis. AKT1-IN-11 also promotes tubulin depolymerization. AKT1-IN-11 can be used for the research of colorectal cancer[1].
CAS Number
3087064-94-3
UNSPSC
12352005
Target
Akt; Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(OC)C(OC)=CC([C@H]2[C@]3([H])[C@@](COC3=O)([H])[C@@H](OCC4=CN(S(C5=CC=C(NC(C)=O)C=C5)(=O)=O)N=N4)C6=CC7=C(OCO7)C=C26)=C1
Molecular Formula
C33H32N4O11S
Molecular Weight
692.69
References & Citations
[1]Lin H, et al. Click-chemistry mediated synthesis of podophyllotoxin triazole ether derivatives: Inhibiting human CRC tumor growth via dual targeting of AKT1 and tubulin. Bioorg Chem. 2025;166:109195.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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