Akt1/Akt2-IN-2
CAT:
804-HY-129119
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Akt1/Akt2-IN-2
- CAS Number: 612847-42-4
- UNSPSC Description: Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells[1].
- Target Antigen: Akt; Caspase
- Type: Reference compound
- Related Pathways: Apoptosis;PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/akt1-akt2-in-2.html
- Purity: 98.57
- Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 18 mg/mL (ultrasonic;warming)
- Smiles: O=C(C1=CC=C2N=C(C3=CC=CC=C3)C(C4=CC=C(CN5CCC(N6C7=CC=CC=C7NC6=O)CC5)C=C4)=NC2=C1)NCCN(CC)CC
- Molecular Weight: 653.82
- References & Citations: [1]Zhao Z, et al. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported