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M464

CAT: 0804-HY-179494Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179494Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor. M464 inhibits pyroptosis and hinders the activation of downstream Caspase-1 expression and the release of IL-1β by impeding ASC oligomerisation and curtailing ROS production. M464 exhibits protective effects against acute lung and liver injury in mice. M464 can be used for the research of NLRP3-related inflammatory diseases[1].
UNSPSC
12352005
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
CC1CC(OC(CCC(OC2=CC=C(C3=CC(SS3)=S)C=C2)=O)=O)C(C(C)C)CC1
Molecular Formula
C23H28O4S3
Molecular Weight
464.66
References & Citations
[1]Wang W, et al. M464 inhibits activation of NLRP3 inflammasome and inflammatory response in mice. Sci Rep. 2025;15 (1) :33878. Published 2025 Sep 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3

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