KMCA-0011

• Description:

  KMCA-0011 is an orally active ɑ2C adrenoceptor antagonist (Ki = 56.7 nM) . KMCA-0011 alleviates depressive behaviors by enhancing BDNF and synaptic plasticity. KMCA-0011 displays favorable metabolic stability, including high plasma stability (99.8% after 120 min) . KMCA-0011 can be used for the research of depression[1].

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  ClC1=CC=C (OC (C (NCCN2CCC (CC3=CC=CC=C3) CC2) =O) =N4) C4=C1

• Molecular Formula:

  C22H24ClN3O2

• Molecular Weight:

  397.90

• References & Citations:

  [1]Seo K, et al. ɑ2C Adrenoceptor antagonist KMCA-0011 alleviated depressive-like behaviors in a maternal separation mouse model. Bioorg Med Chem Lett. 2026 Feb 1;131:130467.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α adrenergic receptor