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PTPN2-IN-2

CAT: 0804-HY-179380Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179380Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTPN2-IN-2 is a potent and orally active PTPN2 inhibitor (IC50 = 7.05 nM) that enhances the IFN-γ signaling pathway. PTPN2-IN-2 inhibits PTP1B with an IC50 of 9.88 nM. PTPN2-IN-2 inhibits tumor growth, promotes the activation and infiltration of tumor immune cells in a B16-OVA mouse model. PTPN2-IN-2 can be used for the research of melanoma[1].
CAS Number
3093350-44-5
UNSPSC
12352005
Target
IFNAR; JAK; Phosphatase; STAT
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC1=C(C(O)=CC(C2=CNC(C(NC3CCCCCC3)=O)=N2)=C1)N4CC(NS4(=O)=O)=O
Molecular Formula
C19H22FN5O5S
Molecular Weight
451.47
References & Citations
[1]Kuang W, et al. Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma. J Med Chem. 2025;68 (22) :24649-24671.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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