PTPN2-IN-2

• Description:

  PTPN2-IN-2 is a potent and orally active PTPN2 inhibitor (IC50 = 7.05 nM) that enhances the IFN-γ signaling pathway. PTPN2-IN-2 inhibits PTP1B with an IC50 of 9.88 nM. PTPN2-IN-2 inhibits tumor growth, promotes the activation and infiltration of tumor immune cells in a B16-OVA mouse model. PTPN2-IN-2 can be used for the research of melanoma[1].

• UNSPSC:

  12352005

• Target:

  IFNAR; JAK; Phosphatase; STAT

• Related Pathways:

  Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  FC1=C(C(O)=CC(C2=CNC(C(NC3CCCCCC3)=O)=N2)=C1)N4CC(NS4(=O)=O)=O

• Molecular Formula:

  C19H22FN5O5S

• Molecular Weight:

  451.47

• References & Citations:

  [1]Kuang W, et al. Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma. J Med Chem. 2025;68 (22) :24649-24671.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3093350-44-5