UB-MBX-46

• Description :

  UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC50s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research[1].

• UNSPSC :

  12352005

• Target :

  P2X Receptor

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Smiles :

  O=C(NNC1=C(C=CC=C1)Cl)C23C(CC4(C)C5(C)C3)CC4(C)C5(C)C2

• Molecular Formula :

  C21H27ClN2O

• Molecular Weight :

  358.90

• References & Citations :

  [1]Oken AC, et al. A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. Nat Commun. 2025 Sep 15;16 (1) :8283.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  P2X7 Receptor