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TPST2-IN-1

CAT: 0804-HY-179288Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179288Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TPST2-IN-1 is a potent and selective TPST2 inhibitor with an IC50 of 946 nM and a Ka of 19.4 μM. TPST2-IN-1 increases the phosphorylation of Stat1 and upregulates the IFNγ-responsive gene CXCL10 by inhibiting TPST2 activity.TPST2-IN-1 exhibits anti-tumor activity and enhances T cell-mediated antitumor immunity characterized by increased infiltration of effector CD8+ T cells. TPST2-IN-1 can be used for the research of cancer, such as colon cancer[1].
UNSPSC
12352005
Target
STAT; Transmembrane Glycoprotein
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C[C@@H]1CC[C@H](CC1)C2=CC=C(C=C2)N3CCN(CC3)C(CCC(NC4=NC(C5=CC(F)=C(C(F)=C5)O)=CS4)=O)=O)O
Molecular Formula
C31H34F2N4O5S
Molecular Weight
612.69
References & Citations
[1]Park SB, et al. Discovery of (4-Phenyl-cyclohexyl) acetate-Derived Tyrosylprotein Sulfotransferase 2 (TPST2) Inhibitors with Potent Anti-Tumor Activity for Immuno-Oncology Applications. J Med Chem. 2025;68 (21) :22401-22427.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT1

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