DNPH1-IN-1

• Description :

  DNPH1-IN-1 (Compound 38) is a potent, cell-active non-nucleoside DNPH1 inhibitor, with a pIC50 of 9.3. DNPH1-IN-1 increases DNA-bound hmdU. DNPH1-IN-1 can be used in the research of breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Glycosidase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC(C2=CC=CC(C(F)(F)F)=C2F)=C(NC3=NC(N[C@@H]4CN(C5=CN=CN=C5)CC4)=C6C=C(C)C=CC6=N3)C=C1)O

• Molecular Formula :

  C31H25F4N7O2

• Molecular Weight :

  603.57

• References & Citations :

  [1]Barlaam B, et al. Discovery and Optimization of a Non-Nucleoside-Based Series of Inhibitors of 2'-Deoxynucleoside 5'-Monophosphate Glycosidase (DNPH1) . J Med Chem. 2025 Nov 27;68 (22) :24381-24403.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported