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KTT-1

CAT: 0804-HY-179216Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179216Size:1 Each
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Description
KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases[1][2].
CAS Number
2397562-26-2
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=CC(C2=CC=CO2)=CC=C1N)C(C=C3)=CC=C3C(N=N4)=CN4CS(=O)(C5=CC=CC=C5)=O
Molecular Formula
C26H21N5O4S
Molecular Weight
499.54
References & Citations
[1]Yumi Ogihara, et al. The HDAC2-selective inhibitor KTT-1 attenuates autoimmune arthritis by inhibiting osteoclast differentiation in mice. bioRxiv. October 21, 2025.|[2]Mishima H, et al. Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor. J Comput Chem. 2023;44 (18) :1604-1609.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2

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