DAA

• Description :

  DAA is a potent autophagy inducer that exhibits antitumor efficacy and enhances anti-PD1 immunotherapy in non-small cell lung cancer (NSCLC) . DAA acts by disrupting the LIC1-RuvB-like AAA ATPase 1 interaction, which activates the GCN2-eIF2α-ATF4 integrated stress response pathway and promotes autophagic cell death. DAA can be used for NSCLC research[1].

• UNSPSC :

  12352005

• Target :

  Autophagy

• Related Pathways :

  Autophagy

• Field of Research :

  Cancer

• Smiles :

  COC1=CC(O)=C(C([C@]2([C@H](OC(C(C)C)=O)[C@H](OC(C(C)C)=O)[C@](O)(C)C3)[C@@]3(O2)C4=O)=O)C4=C1

• Molecular Formula :

  C24H28O10

• Molecular Weight :

  476.47

• References & Citations :

  [1]Huang JL, et al. A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy. Nat Chem Biol. 2025 Oct 16.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported