EIF2B-IN-1

CAT: 0804-HY-179109Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179109Size:1 Each
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Description
EIF2B-IN-1 (Compound A) is an eIF2B inhibitor. EIF2B-IN-1 binds eIF2B. EIF2B-IN-1 stabilises the eIF2B decamer and favours inhibitory eIF2B:eIF2 (αP) complex formation. EIF2B-IN-1 exhibits weak displacement of ISRIB. EIF2B-IN-1 can be used in the research of integrated stress responses[1].
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
F[C@@H]1[C@H](COCC(N(C)C2CCCC3=C2C=C(C4=CC(CN(C)C(C)=O)=CC=C4)C=C3C(F)(F)F)=O)CCNC1
Molecular Formula
C30H37F4N3O3
Molecular Weight
563.63
References & Citations
[1]Shilliday F, et al. A molecular stabiliser of an inhibitory eIF2B-eIF2 (αP) complex activates the Integrated Stress Response. bioRxiv, 2025: 2025.09. 25.678332.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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