LAG-3 PROTAC-1

• Description:

  LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with a DC50 of 0.27 μM. LAG-3 PROTAC-1 can be used in cancer immunology research (pink: LAG-3 ligand (HY-179061) ; blue: CRBN ligand (HY-10984) ; black: linker; CRBN ligand + linker (HY-131888A) ) [1].

• UNSPSC:

  12352005

• Target:

  LAG-3; PROTACs

• Related Pathways:

  Immunology/Inflammation; PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C(NCCCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)[C@H]([C@@H](C4=CC=CC=C4)C5)CN5CC6=CC=CC=N6

• Molecular Formula:

  C34H36N6O5

• Molecular Weight:

  608.69

• References & Citations:

  [1]Vázquez NG, et al. Design and validation of the first-in-class PROTACs for targeted degradation of the immune checkpoint LAG-3. Bioorg Med Chem Lett. 2025 Oct 4;130:130428.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon