LAG-3-IN-1

CAT: 0804-HY-176814Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-176814Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a KD of 0.41 μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research[1].

UNSPSC

12352005

Target

LAG-3

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C([C@@H]1[C@H](CN(C1)CC2=NC=CC=C2)C3=CC=CC=C3)NCC4=CC=C(C=C4)C5=CC=CC=C5

Molecular Formula

C30H29N3O

Molecular Weight

447.57

References & Citations

[1]Abdel-Rahman SA, et al. Discovery and Optimization of LAG-3-Targeted Small Molecules via DNA-Encoded Chemical Library (DEL) Screening for Cancer Immunotherapy. J Med Chem. 2025 Aug 20.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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