JOSD2-IN-1

• Description:

  JOSD2-IN-1 (Compound 31) is a covalent JOSD2 inhibitor with an IC50 value of 1.95 μM. JOSD2-IN-1 inhibits JOSD2, thereby down-regulating KRAS expression. JOSD2-IN-1 exhibits significant anti-proliferative activity against HCT116 cells. JOSD2-IN-1 can be used for research on colorectal cancer[1].

• UNSPSC:

  12352005

• Target:

  Deubiquitinase; Ras

• Related Pathways:

  Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=C2NC (NC ([C@@H]3[C@@]4 ([H]) CN (C#N) C[C@@]34[H]) =O) =NC2=CC=C1) NC56CC7 (C) CC (C6) (C) CC (C7) C5

• Molecular Formula:

  C27H32N6O2

• Molecular Weight:

  472.58

• References & Citations:

  [1]Liu P, et al. Rational DESIGN and Structure-activity relationship study of novel JOSD2 inhibitor against colorectal cancer. Bioorg Chem. 2025 Oct 5;166:109022.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras