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OGG1 activator-1

CAT: 0804-HY-179014Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179014Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) [1].
UNSPSC
12352005
Target
DNA Glycosylase
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology
Smiles
OC1=CC2=C(NC(C3=CC=CN=C3)=C2CCN)C=C1
Molecular Formula
C15H15N3O
Molecular Weight
253.30
References & Citations
[1]Varga M, et al. Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1. J Med Chem. 2025 Nov 13;68 (21) :22455-22483.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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