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α-Glucosidase-IN-98

CAT: 0804-HY-178383Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178383Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC50 of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch /Sucrose (HY-B1779) -challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research[1].
UNSPSC
12352005
Target
Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
COC1=CC(CCC(CCC2=CC=C(C=C2)C#N)=O)=CC=C1O
Molecular Formula
C19H19NO3
Molecular Weight
309.36
References & Citations
[1]Liao XM, et al. Synthesis of diarylpentane derivatives as novel α-Glucosidase inhibitors: Their inhibitory mechanism and hypoglycemic effects. Eur J Med Chem. 2025 Dec 15;300:118161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Glucosidase

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