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G9a-IN-4

CAT: 0804-HY-178378Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178378Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G9a-IN-4 is a G9a inhibitor with high selectivity (IC50 = 32 nM) . G9a-IN-4 shows high selectivity against the other tested lysine/arginine methyltransferases. G9a-IN-4 exhibits high enzymatic activity against G9a and more potent antiproliferative effects against all tested cancer cells. G9a-IN-4 significantly suppresses the H3K9me2 level. G9a-IN-4 triggers autophagy by inducing the production of ROS, thus leading to cell apoptosis and cell cycle arrest at G0/G1 in CT26 colon cells. G9a-IN-4 can be used for the study of colon cancer[1].
UNSPSC
12352005
Target
Apoptosis; Autophagy; GLP Receptor; Histone Methyltransferase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
COC1=CC2=C(N=C(N=C2NC3CCN(CC3)C(C)C)N4CCC5=C(C4C)C=C6OCOC6=C5)C=C1OCCCN7CCCC7
Molecular Formula
C35H48N6O4
Molecular Weight
616.79
References & Citations
[1]Shao M, et al. Discovery of 2-tetrahydroisoquinoline-substituted quinazoline derivatives as lysine methyltransferase G9a inhibitors with in vivo antitumor efficacy. Eur J Med Chem. 2025 Dec 15;300:118113.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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