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AC-340

CAT: 0804-HY-178336Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178336Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AC-340 is a potent hybrid VDR agonist/HDAC inhibitor. AC-340 superinduces VDR target genes (e.g., CYP24A1) and inhibits HDAC6 (IC50 = 0.37 μM) with ~10-fold selectivity over HDAC2. AC-340 induces VDR hyperagonism by causing widespread protein hyperacetylation (e.g., tubulin and H3K9/K27), which leads to elevated H3K27 acetylation on VDR target genes. AC-340 can be used for melanoma cancer research[1].
UNSPSC
12352005
Target
HDAC; Microtubule/Tubulin; VD/VDR
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Smiles
CCC(CC)(C1=CC=C(C=C1)OCCCC(NO)=O)C2=NC(C)=C(S2)CCC(C(C)(C)C)O
Molecular Formula
C26H40N2O4S
Molecular Weight
476.67
References & Citations
[1]Sarmadi F, et al. Hyperagonism of a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule. J Med Chem. 2025 Oct 9;68 (19) :20675-20688.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2; HDAC6

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