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MTORC1-IN-3

CAT: 0804-HY-178192Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178192Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTORC1-IN-3 is a potent and selective mTORC1 inhibitor with an IC50 of 26.38 μM . mTORC1-IN-3 selectively inhibits the phosphorylation of mTORC1 substrates and does not without affect the phosphorylation of mTORC2 substrate. mTORC1-IN-3 can reduce cellular lipid accumulation and induce autophagy. mTORC1-IN-3 can be used for the researches of cancer, immunology, metabolic and neurological disease, such as diabetes and Alzheimer’s disease[1].
UNSPSC
12352005
Target
Autophagy; mTOR
Related Pathways
Autophagy; PI3K/Akt/mTOR
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
CC1(O[C@@H]2[C@H]([C@H](O[C@@H]2O1)CN3C=C(N=N3)COCC4=C(C5=CC(C6=CN=C(N=C6)N)=CC=C5N=C4)NC7=CC=C(C(C(F)(F)F)=C7)F)OCO[C@H]8[C@H](O[C@H]9[C@@H]8OC(C)(O9)C)CN=[N+]=[N-])C
Molecular Formula
C41H43F4N11O9
Molecular Weight
909.84
References & Citations
[1]Palit S, et al. Glycoconjugation of Quinoline as an Effective Strategy for Selective Inhibition of mTORC1. J Med Chem. 2025 Sep 25;68 (18) :19041-19061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTORC1

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