WEE1-IN-13

• Description:

  WEE1-IN-13 (Compound 10) is a highly selective WEE1 kinase inhibitor (IC50=0.7 nM) . WEE1-IN-13 abrogates the G2/M checkpoint and induces tumor cell apoptosis. WEE1-IN-13 is promising for research of solid tumors (e.g., non-small cell lung cancer, ovarian cancer) [1].

• UNSPSC:

  12352005

• Target:

  Wee1

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  C[C@H](C1=C(C2=C(N1C)N=C(N=C2)NC3=CN(N=C3)C4CCN(CC4)C)C#N)C5=CC=CS5

• Molecular Formula:

  C23H26N8S

• Molecular Weight:

  446.57

• References & Citations:

  [1]Knight JL, et al. Harnessing free energy calculations for kinome-wide selectivity in drug discovery campaigns with a Wee1 case study. Nat Commun. 2025 Aug 26;16 (1) :7962.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported