WEE1-IN-12

• Description:

  WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. WEE1-IN-12 can inhibit the proliferation of HT29 cells (IC50: 1.07 μM), and when used in combination with Gemcitabine (HY-17026), the effect is better (IC50: 0.34 μM) . WEE1-IN-12 can be used in the research of tumors such as colon cancer[1].

• UNSPSC:

  12352005

• Target:

  Wee1

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCCCN4CCC(CC4)N5C=C(C=N5)NC6=NC=C(C(OC7CC7)=N6)C(NC8=C(C=CC=C8Cl)Cl)=O)=C3C2=O)=O

• Molecular Formula:

  C38H38Cl2N10O6

• Molecular Weight:

  801.68

• References & Citations:

  [1]Liang S H. Novel (1 H-Pyrazol-4-ylamino) pyrimidine Derivatives as Wee1 Inhibitors for Treatment of Cancer. ACS Medicinal Chemistry Letters, 2025.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3069940-37-7]