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LMDP10

CAT: 0804-HY-178054-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178054-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LMDP10 is an orally active 3-amino quinazoline derivative with Keap1-Nrf2 pathway activation activity. LMDP10 binds to Keap1 to inhibit Keap1-Nrf2 interaction, thereby activating the Nrf2 pathway. LMDP10 elevates Nrf2, SOD, and GSH levels, reduces MDA and TNF-α levels, attenuates neurodegeneration, and improves memory function in Alzheimer’s disease (AD) rats. LMDP10 can be used for the study of AD[1].
CAS Number
2760446-25-9
UNSPSC
12352005
Target
Drug Derivative; Keap1-Nrf2
Related Pathways
NF-κB; Others
Field of Research
Neurological Disease
Smiles
O=C(N(CC(N1NC(C2=CC=CC=C2)=O)=NC3=C(C=CC=C3)C1=O)C4=CC=C(F)C=C4)C5=CC=CC=C5
Molecular Formula
C29H21FN4O3
Molecular Weight
492.50
References & Citations
[1]Maheta P, et al. Neuroprotective Effects of a 3-Amino Quinazoline Derivative via Keap1-Nrf2 Pathway Activation in an ICV-STZ-Induced Rat Model of Sporadic Alzheimer's Disease. ACS Chem Neurosci. 2025 Sep 17;16 (18) :3611-3622.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-[2-[(N-benzoyl-4-fluoroanilino)methyl]-4-oxoquinazolin-3-yl]benzamide
CAS Number2760446-25-9
PubChem CID178421034
IUPAC NameN-[2-[(N-benzoyl-4-fluoroanilino)methyl]-4-oxoquinazolin-3-yl]benzamide
Molecular FormulaC29H21FN4O3
Molecular Weight492.5
XLogP4.9
Topological Polar Surface Area82.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity859
SMILES
C1=CC=C(C=C1)C(=O)NN2C(=NC3=CC=CC=C3C2=O)CN(C4=CC=C(C=C4)F)C(=O)C5=CC=CC=C5
InChI
InChI=1S/C29H21FN4O3/c30-22-15-17-23(18-16-22)33(28(36)21-11-5-2-6-12-21)19-26-31-25-14-8-7-13-24(25)29(37)34(26)32-27(35)20-9-3-1-4-10-20/h1-18H,19H2,(H,32,35)
InChIKey
BXEOGVYDILYVAK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-[(N-benzoyl-4-fluoroanilino)methyl]-4-oxoquinazolin-3-yl]benzamide
CAS: 2760446-25-9
CID: 178421034
Formula: C29H21FN4O3
MW: 492.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight492.5
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass492.15976871
Monoisotopic Mass492.15976871
Topological Polar Surface Area82.1 Ų
Heavy Atom Count37
Formal Charge0
Complexity859
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19272930-01LMDP10

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