Neuroprotective agent 14

• Description :

  Neuroprotective agent 14 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 14 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 14 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) [1].

• UNSPSC :

  12352005

• Target :

  Autophagy

• Related Pathways :

  Autophagy

• Field of Research :

  Neurological Disease

• Smiles :

  CC1=NC2=C(C=C(C=C2)OCC3=CC=C(C=C3)C(F)(F)F)N1

• Molecular Formula :

  C16H13F3N2O

• Molecular Weight :

  306.28

• References & Citations :

  [1]Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68 (17) :18530-18552.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3086460-57-0]