Neuroprotective agent 12

• Description :

  Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases[1].

• UNSPSC :

  12352005

• Target :

  Heme Oxygenase (HO) ; NF-κB; Phosphodiesterase (PDE)

• Related Pathways :

  Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Smiles :

  COC1=C(OC2CCCC2)C=CC(/C=C/C(NC3=CC=C(N(C)C)C=C3)=O)=C1

• Molecular Formula :

  C23H28N2O3

• Molecular Weight :

  380.48

• References & Citations :

  [1] Lu J, et al. Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury. ACS Chem Neurosci. 2020 Aug 5; 11 (15) :2348-2360.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HO-1; PDE4

• CAS Number :

  [2522599-69-3]