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Neuroprotective agent 12

CAT: 0804-HY-174339Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174339Size:1 Each
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Description
Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases[1].
CAS Number
2522599-69-3
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; NF-κB; Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
COC1=C(OC2CCCC2)C=CC(/C=C/C(NC3=CC=C(N(C)C)C=C3)=O)=C1
Molecular Formula
C23H28N2O3
Molecular Weight
380.48
References & Citations
[1] Lu J, et al. Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury. ACS Chem Neurosci. 2020 Aug 5; 11 (15) :2348-2360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HO-1; PDE4

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