Neuroprotective agent 13

• Description:

  Neuroprotective agent 13 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 13 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 13 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) [1].

• UNSPSC:

  12352005

• Target:

  Autophagy

• Related Pathways:

  Autophagy

• Field of Research:

  Neurological Disease

• Smiles:

  OCC1=NC2=C(C=C(C=C2)NCC3=CC=C(C=C3)C(F)(F)F)N1

• Molecular Formula:

  C16H14F3N3O

• Molecular Weight:

  321.30

• References & Citations:

  [1]Simeon P, et al. Discovery of Functionalized 1H-Benzo[d]imidazoles That Confer Protective Effects in a Phenotypic CLN3 Disease Patient-Derived iPSC Model. J Med Chem. 2025 Sep 11;68 (17) :18530-18552.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3086460-35-4]