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H3R antagonist 8

CAT: 0804-HY-178016Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178016Size:1 Each
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Description
H3R antagonist 8 is a selective nonimidazole histamine H3 receptor antagonist (IC50 = 0.35 μM) . H3R antagonist 8 exhibits hERG channel blockade activity (IC50 = 0.67 μM) . H3R antagonist 8 inhibits seizures by antagonizing H3 receptor. H3R antagonist 8 reduces tonic hind limb extension (THLE) in mice in the maximal electroshock seizure (MES) model (ED50 = 20.21 mg/kg) and and shortens pentylenetetrazol (PTZ) -induced total movement distance in AB strain zebrafish larvae. H3R antagonist 8 can be used for the study of epilepsy[1].
CAS Number
3097193-89-7
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CCN(CC)CCCOC1=CC=C(C2=C(C3=CC=CC=C3Cl)OC(C)=N2)C=C1
Molecular Formula
C23H27ClN2O2
Molecular Weight
398.93
References & Citations
[1]Deng M, et al. Synthesis of nonimidazole H3 receptor antagonists containing oxazole moiety and their antiseizure activity. Bioorg Chem. 2025 Sep;164:108888.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor

Chemical Information

3-[4-[5-(2-chlorophenyl)-2-methyl-1,3-oxazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
CAS Number3097193-89-7
PubChem CID178421030
IUPAC Name3-[4-[5-(2-chlorophenyl)-2-methyl-1,3-oxazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
Molecular FormulaC23H27ClN2O2
Molecular Weight398.9
XLogP5.8
Topological Polar Surface Area38.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count28
Formal Charge0
Complexity440
SMILES
CCN(CC)CCCOC1=CC=C(C=C1)C2=C(OC(=N2)C)C3=CC=CC=C3Cl
InChI
InChI=1S/C23H27ClN2O2/c1-4-26(5-2)15-8-16-27-19-13-11-18(12-14-19)22-23(28-17(3)25-22)20-9-6-7-10-21(20)24/h6-7,9-14H,4-5,8,15-16H2,1-3H3
InChIKey
GXZJKYZMGAGUIC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[4-[5-(2-chlorophenyl)-2-methyl-1,3-oxazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
CAS: 3097193-89-7
CID: 178421030
Formula: C23H27ClN2O2
MW: 398.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.9
XLogP35.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass398.1761058
Monoisotopic Mass398.1761058
Topological Polar Surface Area38.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity440
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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