MS99-β-Gal

• Description :

  MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM) . MS99-β-Gal can be used for the research of cancer[1].

• Product Name Alternative :

  Gal-MS99

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK) ; PROTACs

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  CC(O[C@@H]1[C@H]([C@H]([C@H](O[C@H]1OC2=CC=C(C=C2)COC(O[C@H]3CN([C@@H](C3)C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C([C@H](C(C)(C)C)NC(CCCC(N6CCC(CC6)C7=CC(OC(C)C)=C(NC8=NC=C(C(NC9=C(S(=O)(C(C)C)=O)C=CC=C9)=N8)Cl)C=C7C)=O)=O)=O)=O)COC(C)=O)OC(C)=O)OC(C)=O)=O

• Molecular Formula :

  C78H96ClN9O20S2

• Molecular Weight :

  1579.23

• References & Citations :

  [1]Chang M, et al. Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs. J Med Chem. 2024 May 9;67 (9) :7301-7311.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3055593-63-7]