Products for Research Use Only
RegisterLogin

NAE-IN-3

CAT: 0804-HY-177936Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-177936Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 μM) . NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research[1].
CAS Number
951950-33-7
UNSPSC
12352005
Target
NEDD8-activating Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CNC(CNC(COC1=CC2=C(N=C3N(CCC3)C2=O)C=C1)=O)=O)O
Molecular Formula
C17H18N4O6
Molecular Weight
374.35
References & Citations
[1]Zhong HJ, et al. Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening. Biochimie. 2012 Nov;94 (11) :2457-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-115537-01NAE-IN-M22
HY-163524NAE-IN-2
HY-161268-01NAE-IN-1
HY-W081226-013,3,3-Trifluoropropionyl chloride
HY-W127810-013,3',3''-Nitrilotripropionic Acid
HY-W4403031,1',3,3,3',3'-Hexamethylindotricarbocyanine (perchlorate)
HY-W1146693- (3- (3-Ethoxy-3-oxopropoxy) propoxy) propanoicacid
HY-D1075-011,1',3,3,3',3'-Hexamethylindodicarbocyanine (iodide)
HY-178928KV1.3-IN-3
HY-176547FGFR2/3-IN-3

Alternative Products

CatalogName
GTR19274163-01NAE-IN-3
T209896-01NAE-IN-2
MBS5764978NAE-IN-M22
GTR19261992-01NAE-IN-1
bs-75587C-01MLN4924 [NAE Inhibitor]
217578NAE Inhibitor, MLN4924
JBS-EN-122LNae I, L pack
G2400α-Naphthol Acetate Esterase Stain Kit (α-NAE Method)
PC68253,3,3-Trifluoropropyl 3,3,3-trifluoropropanoate
QMC01729-013- (3,3,3-Trifluoropropoxy) pyridine

Popular Products