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KB05yne

CAT: 0804-HY-177554-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-177554-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KB05yne is a site-selective, alkyne-functionalized electrophilic "scout" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type forms of target proteins (e.g., CDKN2AIP, HPCAL1) but not their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for site-specific covalent ligand discovery and optimization for structurally and functionally diverse proteins, particularly in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins[1].
CAS Number
2724919-69-9
UNSPSC
12352101
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Cancer
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCCC#C)C1=CC=C(N(C2=CC=C(Br)C=C2)C(C=C)=O)C=C1
Molecular Formula
C22H21BrN2O2
Molecular Weight
425.32
References & Citations
[1]Crowley VM, et al. Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization. ACS Cent Sci. 2021 Apr 28;7 (4) :613-623.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19280660-01KB05yne

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