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KB05yne

CAT: 0013-GTR19280660-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19280660-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KB05yne is a site-selective, alkyne-functionalized electrophilic "fragment" probe, crafted for covalent ligand discovery with preferential reactivity towards specific cysteine residues in proteins. It robustly labels wild-type target proteins (such as CDKN2AIP, HPCAL1) but not their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne is utilized in the discovery and optimization of site-specific covalent ligands for a range of structurally and functionally diverse proteins, particularly in studying cysteine residues within cancer-related or hard-to-purify proteins.
CAS Number
2724919-69-9
Smiles
O=C (C=C) N (C1=CC=C (Br) C=C1) C2=CC=C (C=C2) C (=O) NCCCCC#C
Molecular Formula
C22H21BrN2O2
Molecular Weight
425.33
Notes
For research use only.

Alternative Products

CatalogName
HY-177554-01KB05yne

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