Products for Research Use Only
RegisterLogin

AXT-914

CAT: 0804-HY-177303Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-177303Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AXT-914 is a Calcium-sensing receptor (CaSR) inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research[1][2].
CAS Number
717104-43-3
UNSPSC
12352005
Target
CaSR; SARS-CoV
Related Pathways
Anti-infection; GPCR/G Protein
Field of Research
Infection; Endocrinology; Metabolic Disease
Smiles
O=C1N=C(C2=C(N1CC3=CC=C(C=C3)Br)C=CC(OCC#C)=C2)C4=CC=C(C(C)C)C=C4
Molecular Formula
C27H23BrN2O2
Molecular Weight
487.39
References & Citations
[1]Brun J, et al. Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals. Antiviral Res. 2025 May;237:106123. |[2]Letz S, et al. Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia. PLoS One. 2014 Dec 15;9 (12) :e115178.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-122018GS-9148
HY-116119BDF 9148

Alternative Products

CatalogName
T212185-01AXT-914
5130BCuvette for Hitachi 717 & 914
551565Tensin 1 (aa902-914)
GTR17699353Tensin 1 (aa902-914) Antibody
STJ73088Anti-Tensin 1 (aa902-914) antibody
PTX26375Anti-Human CD127/IL7R (ADX-914)
GTR18988697Tensin 1 (aa902-914) Immunizing Peptide
4021120Stereo Inclined Microscope, Model SM-914
HB016036-01Research Grade Anti-Human CD127/IL7R (ADX-914)
A136785Anti-CD127/IL7R (ADX-914) Biosimilar (Monoclonal, IgG)

Popular Products