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LAB687

CAT: 0804-HY-177291Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177291Size:1 Each
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Description
LAB687 (Compound 2a) is a Microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9 nM for the secretion of apoB from HepG2 cells. LAB687 is also a Smoothened (Smo) antagonist with IC50s of 2.48 and 3.42 μM for mouse and human Smo receptor, respectively. LAB687 can lower the level of triglycerides and LDL cholesterol and inhibits the Hedgehog signaling pathway[1].
CAS Number
256397-11-2
UNSPSC
12352005
Target
Hedgehog; Microsomal Triglyceride Transfer Protein (MTP) ; Smo
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer; Cardiovascular Disease
Smiles
COC(N[C@@H]1CC2=CC=C(C=C2C1)NC(C(C=CC=C3C)=C3C4=CC=C(C(F)(F)F)C=C4)=O)=O
Molecular Formula
C26H23F3N2O3
Molecular Weight
468.47
References & Citations
[1]Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett. 2009 Jan 15;19 (2) :328-31. |[2]Prashad M, et al. Process research and development of a MTP inhibitor: Another case of disappearing polymorphs upon scale-up[J]. Organic Process Research & Development, 2010, 14 (4) : 878-882.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T212506-01LAB687

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