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LAB687

CAT: 0013-GTR19264696-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264696-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.
CAS Number
256397-11-2
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
C (NC=1C=C2C (=CC1) C[C@@H] (NC (OC) =O) C2) (=O) C3=C (C (C) =CC=C3) C4=CC=C (C (F) (F) F) C=C4
Molecular Formula
C26H23F3N2O3
Molecular Weight
468.47
Storage Conditions
-20°C
Notes
For research use only.

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