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DMBP

CAT: 0804-HY-177120-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-177120-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMBP is a VPS41 inhibitor. DMBP induces methuosis and inhibits autophagy in cancer cells. DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes. DMBP effectively inhibits metastasis in a mouse metastatic melanoma model. DMBP can be used for the study of melanoma[1].
CAS Number
133156-42-0
UNSPSC
12352005
Target
Autophagy
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Purity
99.7800
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=C(CCC2=CC=CC=C2)C=C(O)C(C/C=C(C)\C)=C1O
Molecular Formula
C21H24O4
Molecular Weight
340.41
References & Citations
[1]Liu Y, et al. Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells. Cell Chem Biol. 2023 Feb 16;30 (2) :130-143.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate
CAS Number133156-42-0
PubChem CID15131229
IUPAC Namemethyl 2,4-dihydroxy-3-(3-methylbut-2-enyl)-6-(2-phenylethyl)benzoate
Molecular FormulaC21H24O4
Molecular Weight340.4
XLogP5.8
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count25
Formal Charge0
Complexity449
SMILES
CC(=CCC1=C(C=C(C(=C1O)C(=O)OC)CCC2=CC=CC=C2)O)C
InChI
InChI=1S/C21H24O4/c1-14(2)9-12-17-18(22)13-16(19(20(17)23)21(24)25-3)11-10-15-7-5-4-6-8-15/h4-9,13,22-23H,10-12H2,1-3H3
InChIKey
LYKKPZPBEBHSMF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate
CAS: 133156-42-0
CID: 15131229
Formula: C21H24O4
MW: 340.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight340.4
XLogP35.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass340.16745924
Monoisotopic Mass340.16745924
Topological Polar Surface Area66.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity449
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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