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RhQ-DMB

CAT: 0804-HY-163204Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163204Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RhQ-DMB is a potent inhibitor of P-gp. RhQ-DMB exhibits high affinity and inhibitory activity in yeast strains expressing CmABCB1[1].
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rhq-dmb.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=C(OC)C=CC=C1OC)C2=CC=CC=C2C3=C4C=C5CCC[NH+]=C5C=C4OC6=CC7=C(CCCN7)C=C63.[Cl-]
Molecular Formula
C35H33ClN2O5
Molecular Weight
597.10
References & Citations
[1]Miwa S, et al. Structure–ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported