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AS2795440

CAT: 0804-HY-177091Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177091Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS2795440 is a PIKfyve inhibitor. AS2795440 selectively inhibits proinflammatory cytokine such as IL-12p40 and IL-6 production and B cell activation without affecting Ca2+ signaling. AS2795440 significantly reduces joint inflammation and bone loss in adjuvant-induced arthritis (AIA) mice model. AS2795440 can be used for inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis and inflammatory bowel disease research[1].
CAS Number
2171506-45-7
UNSPSC
12352005
Target
Interleukin Related; MHC; PIKfyve
Related Pathways
Immunology/Inflammation; PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Smiles
CC(NC1=C2N=C(C(NC3=C(N=CC(C4=CC=C(N=C4)C(CC5)=CCN5C(C)C)=C3)C)=O)C=C1)=C2C
Molecular Formula
C29H32N6O
Molecular Weight
480.60
References & Citations
[1]Terajima M, et al. Inhibition of c-Rel DNA binding is critical for the anti-inflammatory effects of novel PIKfyve inhibitor. Eur J Pharmacol. 2016 Jun 5;780:93-105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-23; IL-6; MHC II

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CatalogName
T212568-01AS2795440

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