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AS2795440

CAT: 0931-T212568-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212568-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2171506-45-7
Target
Interleukin, PI3K, MHC
Related Pathways
Immunology/Inflammation, PI3K/Akt/mTOR signaling
Bioactivity
AS2795440 is a PIKfyve inhibitor. It selectively suppresses the production of pro-inflammatory cytokines such as IL-12p40 and IL-6 and the activation of B cells, without affecting Ca2+ signaling. In a mouse model of adjuvant-induced arthritis (AIA), AS2795440 significantly reduces joint inflammation and bone loss. This compound is useful for researching inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
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O=C(NC=1C=C(C=NC1C)C=2C=NC(=CC2)C3=CCN(CC3)C(C)C)C4=NC5=C(C=C4)NC(=C5C)C
Molecular Formula
C29H32N6O
Molecular Weight
480.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
M17015AS2795440

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