M-1111

• Description :

  M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1) . M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer[1].

• UNSPSC :

  12352005

• Target :

  MTOR

• Related Pathways :

  PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCOCC5=CN(CCOCCOCCOCCOCCOCCOCCOCCNC(CCCCN6C7=C(C(N)=NC=N7)C(C8=CC(N=C(N)O9)=C9C=C8)=N6)=O)N=N5)CC4)OC)C)=O)=O

• Molecular Formula :

  C89H134N12O23

• Molecular Weight :

  1740.08

• References & Citations :

  [1]Kevan Shokat, et al. Disclosed herein, inter alia, are compounds and methods of using the same for modulating the activity of mTORCl. WO2016040806.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MTORC1

• CAS Number :

  [1887095-86-4]