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M-1111

CAT: 0804-HY-176948Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176948Size:1 Each
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Description
M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1) . M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer[1].
CAS Number
[1887095-86-4]
UNSPSC
12352005
Target
MTOR
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCOCC5=CN(CCOCCOCCOCCOCCOCCOCCOCCNC(CCCCN6C7=C(C(N)=NC=N7)C(C8=CC(N=C(N)O9)=C9C=C8)=N6)=O)N=N5)CC4)OC)C)=O)=O
Molecular Formula
C89H134N12O23
Molecular Weight
1740.08
References & Citations
[1]Kevan Shokat, et al. Disclosed herein, inter alia, are compounds and methods of using the same for modulating the activity of mTORCl. WO2016040806.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTORC1

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