GSNOR-IN-1

CAT: 0804-HY-176712Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-176712Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSNOR-IN-1, a prodrug of GSNOR-IN-2 , is a BBB-penetrable S-nitrosoglutathione reductase (GSNOR) inhibitor. GSNOR-IN-1 has significant protective activity against OGD/R-induced injury. GSNOR-IN-1 regulates calcium signaling and synaptic function via Clstn1 S-nitrosation and inhibits neuronal apoptosis. GSNOR-IN-1 significantly reduces infarct volume while improving neurological deficits in ischemic stroke rat models. GSNOR-IN-1 has neuroprotective activity, promising for ischemic stroke research[1].

UNSPSC

12352005

Target

Apoptosis; GSNOR

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Smiles

O=C(OC)C1=CC2=C(C=C(C3=CC=C(N4C=NC=C4)C=C3)N2C5=CC(OCC)=C(C=C5)C(N)=O)C=C1

Molecular Formula

C28H24N4O4

Molecular Weight

480.51

References & Citations

[1]Liang Z, et al. Design, Synthesis, and Anti-ischemic Stroke Activity Evaluation of Novel GSNOR Inhibitors. J Med Chem. 2025 Jun 26;68 (12) :12969-12990.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T212135-01	GSNOR-IN-1
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