KBD4466

CAT: 0804-HY-176553Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-176553Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KBD4466 is an orally active potent TLR7 and TLR8 inhibitor with IC50s of 0.9 nM and 2.8 nM, respectively. KBD4466 inhibits the expression of inflammatory cytokines IL-6 and IFN-α. KBD4466 improves disease progression and survival in the BXSB/MpJ mouse model of Systemic Lupus Erythematosus (SLE) . KBD4466 can be used in the study of autoimmune diseases[1].

CAS Number

3023713-87-0

UNSPSC

12352005

Target

IFNAR; Interleukin Related; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CN1CCC(C2=NN=C([C@]34CN(C[C@]3(C4)C(F)(F)F)C5=C6C=CC=NC6=C(C=C5)C#N)O2)CC1

Molecular Formula

C24H23F3N6O

Molecular Weight

468.47

References & Citations

[1]Yuan Y, et al. Discovery of KBD4466, a Selective TLR 7/8 Inhibitor, for the Treatment of Autoimmune Diseases. J Med Chem. 2025 Jul 1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-6; TLR7; TLR8

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